The effect of perturbations in reconstructing network structure

نویسندگان

  • Florian Markowetz
  • Rainer Spang
چکیده

A Bayesian network is a graph-based representation of a joint probability distribution that captures properties of conditional independence between variables. This representation consists of two components. The first component is a directed acyclic graph (DAG), where the nodes represent genes and arrows between nodes indicate that one gene directly regulates the expression of another gene. The second component describes a conditional distribution for each node given its parents in the graph.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Reconstructing human push recovery reactions using a three dimensional under-actuated bipedal robot

This paper presents the ability of hybrid zero dynamics (HZD) feedback control method to reproduce human like movements for walking push recovery of an under-actuated 3D biped model. The balance recovery controller is implemented on a three-dimensional under-actuated bipedal model subjected to a push disturbance. The biped robot model is considered as a hybrid system with eight degrees of freed...

متن کامل

A Self-Reconstructing Algorithm for Single and Multiple-Sensor Fault Isolation Based on Auto-Associative Neural Networks

Recently different approaches have been developed in the field of sensor fault diagnostics based on Auto-Associative Neural Network (AANN). In this paper we present a novel algorithm called Self reconstructing Auto-Associative Neural Network (S-AANN) which is able to detect and isolate single faulty sensor via reconstruction. We have also extended the algorithm to be applicable in multiple faul...

متن کامل

Sensitivity Analysis of the Effect of Pore Structure and Geometry on Petrophysical and Electrical Properties of Tight Media: Random Network Modeling

Several methodologies published in the literature can be used to construct realistic pore networks for simple rocks, whereas in complex pore geometry formations, as formed in tight reservoirs, such a construction still remains a challenge. A basic understanding of pore structure and topology is essential to overcome the challenges associated with the pore scale modeling of tight porous media. A...

متن کامل

Evaluating the Effect of Perturbations in Reconstructing Network Topologies

Many different Bayesian network models have been suggested to reconstruct gene expression networks from microarray data. However, little attention has been payed to the effects of small sample size and the stability of the solution. We engage in a systematic investigation of these issues. As a starting point for further research we introduce the κ-network. It is a small Bayesian network model (...

متن کامل

Modeling gene regulatory networks: Classical models, optimal perturbation for identification of network

Deep understanding of molecular biology has allowed emergence of new technologies like DNA decryption.  On the other hand, advancements of molecular biology have made manipulation of genetic systems simpler than ever; this promises extraordinary progress in biological, medical and biotechnological applications.  This is not an unrealistic goal since genes which are regulated by gene regulatory ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003